<p>Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells</p>
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چکیده
منابع مشابه
Gossypol-Induced Differentiation in Human Leukemia HL-60 Cells
The main treatment of leukemia is traditional radiochemotherapy, which is associated with serious side effects. In the past twenty years, differentiation was found as an important effective measure to treat leukemia with fewer side effects. Gossypol, a natural compound which has been used as an effective contraceptive drug, has been proposed to be a potent drug to treat leukemia, but the differ...
متن کاملLantadene A-induced apoptosis in human leukemia HL-60 cells
Objectives: Lantadene A (LA, 22β-angeloyloxy-3-oxoolean-12-en-28-oic acid) a pentacyclic, triterpenoid isolated from the leaves of the obnoxious weed, Lantana camara L. was evaluated for apoptosis induction in the human leukemia HL-60 cell line. Materials and Methods: The effect of LA on cell proliferation of HL-60 cancer cells was determined by using the MTT assay. The morphological effects of...
متن کاملChlorogenic acid induced apoptosis and inhibition of proliferation in human acute promyelocytic leukemia HL‑60 cells.
Chlorogenic acid (CA), is found in high abundance in the leaves of a number of plants and has antibacterial, antiphlogistic, antimutagenic, antioxidant and other biological activities. It reportedly possesses antitumor activity via the induction of apoptosis in chronic myelogenous leukemia (CML) cell lines, including U937 and K562 cells. However, the effects of CA on human acute promyelocytic l...
متن کاملBcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells.
The Bcl2 protein inhibits apoptosis (programmed cell death) induced by a variety of noxious stimuli. However, relatively little is known about its effect on apoptosis that occurs after terminal differentiation. Bcl2 protein levels decrease during differentiation of myeloid cells into granulocytes that subsequently undergo apoptosis, but the potential role of Bcl2 in coupling survival and differ...
متن کاملBc12 Inhibits Apoptosis Associated With Terminal Differentiation of HL-60 Myeloid Leukemia Cells
The BC12 protein inhibits apoptosis (programmed cell death) induced by a variety of noxious stimuli. However, relatively l i l e is known about its effect on apoptosis that occurs after terminal differentiation. BC12 protein levels decrease during differentiation of myeloid cells into granulocytes that subsequently undergo apoptosis, but the potential role of BC12 in coupling survival and diffe...
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ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2019
ISSN: 1177-8881
DOI: 10.2147/dddt.s189969